PO-01-154 INTER-OPERATOR SEGMENTATION VARIABILITY INDUCES HIGH PREMATURE VENTRICULAR CONTRACTIONS LOCALIZATION UNCERTAINTY AT THE HEART BASE

Electrocardiographic imaging (ECGI) is a promising tool for the treatment and diagnosis of cardiac arrhythmias. ECGI estimates non-invasively electrical activity heart using body surface potentials (BSPs) obtained at in combination with specific CT/MRI based anatomical models defined electrode positions. In order to solve inverse problem first step be considered indeed image segmentation mesh generation. Our main purpose evaluate effect inter-operator variability on PVC localization. Eight different segmentations from same single subject CT-scans were performed by researchers within consortium Imaging. For all generated meshes, eight ventricular stimulation protocols used; left right free walls (LV, RV), apex, outflow tract (LVOT, RVOT), septum, two locations base (LVB, RVB). BSPs computational models. We designed test cases: without uncertainty. A, no uncertainty considered. B, we geometries starting one BSP reference geometry. each case protocol computed solution Method Fundamental Solutions assessed Localization Error (LE) pacing sites. quantify also difference between LEs tests B A. mean LV, RV, LVOT, RVOT, LVB RVB pacings are 7, 5, 12, 14, 18, 13, 15 mm, respectively. 17, 23, 16, 23 The average differences 0, -1,5, 8, -1, 3, 8 This study shows that localization more important LVB. believe high due heart. These findings suggest can have significant impact its interpretability clinical applications; therefore, careful strongly recommended, especially